Sildenafil Citrate Dosage Forms and Available Strengths

This medicine does not protect you against sexually transmitted diseases (including HIV or AIDS). Use protective measures and ask your doctor if you have any questions about this. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Further information

Ask your healthcare professional how you should dispose of any medicine you do not use. Store mixed oral liquid in the refrigerator. Throw away any unused mixed Revatio® oral liquid after 60 days. It is important that you tell all of your doctors that you take sildenafil. If you need emergency medical care for a heart problem, it is important that your doctor knows when you last took sildenafil.

How it works

Do not use this medicine if you are also using a nitrate medicine, often used to treat angina or high blood pressure. Some illegal ("street") drugs called "poppers" (such as amyl nitrate, butyl nitrate, or nitrite). Do not use this medicine if you also use riociguat (Adempas®). If you will be taking this medicine for pulmonary arterial hypertension, your doctor will want to check your progress at sildenafil premature ejaculation regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Check with your doctor immediately if any of the following side effects occur: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Some side effects may occur that usually do not need medical attention.

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These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Other side effects not listed may also occur in some patients.

Why choose us as your Sildenafil manufacturer?

If you take sildenafil for pulmonary arterial hypertension, do not take Viagra®, Vibrique™ or other PDE5 inhibitors, including tadalafil (Cialis®) or vardenafil (Levitra®). If you take too much sildenafil or take it together with these medicines, the chance for side effects will be higher. It is important to tell your doctor about any heart problems you have now or may have had in the past. This medicine can cause serious side effects in patients with heart problems. If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately.

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This condition may require prompt medical treatment to prevent serious and permanent damage to your penis. If you experience a sudden loss of vision in one or both eyes, contact your doctor immediately. Check with your doctor right away if you have a sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears. If you already use medicine for high blood pressure (hypertension), sildenafil could make your blood pressure go too low. Call your doctor right away if you have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, sweating, or unusual tiredness or weakness. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects.

Parameter	Value	Description	Notes
Absorption	Rapid	Peak plasma levels in 30-120 mins	After oral administration
Bioavailability	40%	Percentage of dose reaching systemic circulation	Subject to food effects
Half-life	4 hours	Time for plasma concentration to reduce by half	---
Metabolism	Liver (CYP3A4 enzymes)	Mainly via CYP3A4 and CYP2C9
Excretion	Feces and urine	80% via feces, 13% via urine

You may report side effects to the FDA at 1-800-FDA-1088.

Other Uses for Sildenafil

Children 1 year of age and older weighing 45 kilograms (kg) or more—20 mg 3 times a day. However the dose is usually not more than 40 mg 3 times a day. Children 1 year of age and older weighing 20 to 45 kg—20 mg 3 times a day. Children 1 year of age and older weighing 20 kg or less—10 mg 3 times a day. Children younger than 1 year of age—Use and dose must be determined by your doctor.

Sildenafil Tablets or Oral Suspension for PAH

For oral dosage forms (suspension or tablets): If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Introduction: Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.

• Sildenafil citrate is a medication used primarily to treat erectile dysfunction.
• It belongs to the class of drugs called phosphodiesterase type 5 inhibitors.
• Sildenafil was originally developed to treat angina and hypertension.
• The drug works by increasing blood flow to the penis during stimulation.
• It is commonly sold under the brand name Viagra.
• Sildenafil is available by prescription and as generics.
• The typical dose is 50 mg taken about an hour before activity.
• Common side effects include headaches, flushing, and nasal congestion.

Aim: Assess the tolerability and efficacy of sildenafil initiated at the 100-mg dose in men with ED.

What happens if I overdose?

For treatment of erectile dysfunction:For oral dosage form (tablets):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. Your doctor may adjust your dose if needed.Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose if needed.Children—Use is not recommended.For oral dosage form (film):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose as needed.Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse.

Patient resources

Your doctor may adjust your dose as needed.Children—Use is not recommended. For oral dosage form (tablets):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose if needed.Children—Use is not recommended. Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose if needed. Methods: Men with ED (score < or =25 on the Erectile Function domain of the International Index of Erectile Function) who had received < or =6 total doses of a phosphodiesterase type 5 inhibitor and none within 4 weeks were randomized to 8 weeks of double-blind, placebo-controlled (DBPC), fixed-dose treatment (50 or 100 mg sildenafil or placebo) followed by 4 weeks of open-label flexible-dose sildenafil (50 or 100 mg). Main outcome measures: Efficacy, tolerability, treatment satisfaction, and other end points were measured at baseline and/or the end of the double-blind and open-label phases and compared between placebo and sildenafil initiated at doses of 50 and 100 mg.

• Sildenafil is available in various dosages: 25 mg, 50 mg, 100 mg.
• Starting dose depends on individual health and response.
• Dose adjustments should be done under medical supervision.
• Overuse may lead to increased side effects.
• Missing a dose is generally safe; do not double up.
• The drug may be taken with or without food.
• It’s generally recommended to avoid heavy meals before taking.
• Always follow your healthcare provider’s guidance.

Results: Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and 100 mg compared with placebo.

• Sildenafil may interact with other medications, increasing risks.
• Significant interactions include nitrates and alpha-blockers.
• Patients should disclose all medications to their doctor.
• Combining with certain drugs can cause dangerous drops in blood pressure.
• Regular liver function monitoring may be necessary.
• Some herbal supplements also have interaction potential.
• Avoiding certain foods and medications reduces risks.
• Proper management improves treatment efficacy.

At the end of DBPC treatment, 56% of men on the 100-mg dose felt no anxiety about the next intercourse attempt compared with 39% in the 50-mg group (odds ratio 2.03; P = 0.0197). Changes in functional scores from baseline were not statistically significant with the 100-mg dose compared with the 50-mg dose in the DBPC.

Use	Evidence Level	Description	Caution
Altitude Sickness	Experimental	Vasodilation might improve oxygenation	Not FDA approved, consult specialist
Premature Ejaculation	Anecdotal evidence	Local vasodilation effects may extend ejaculatory latency	Limited data
Cold-induced Vasospasm	Off-label	May alleviate symptoms of vasospasm	Requires medical supervision

Measures of treatment satisfaction and sexual experience significantly favored the 100-mg dose compared with the 50-mg dose in the DBPC.

Utilisation dans l'hypertension artérielle pulmonaire

Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. For oral dosage form (film):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose as needed. For treatment of pulmonary arterial hypertension:For oral dosage forms (suspension or tablets):Adults—20 milligrams (mg) 3 times a day. Your doctor may adjust your dose as needed and tolerated.

Serious Side Effects

However, the dose is usually not more than 80 mg 3 times a day.Children 1 year of age and older weighing 45 kilograms (kg) or more—20 mg 3 times a day. However the dose is usually not more than 40 mg 3 times a day.Children 1 year of age and older weighing 20 to 45 kg—20 mg 3 times a day.Children 1 year of age and older weighing 20 kg or less—10 mg 3 times a day.Children younger than 1 year of age—Use and dose must be determined by your doctor. For oral dosage forms (suspension or tablets):Adults—20 milligrams (mg) 3 times a day. Adults—20 milligrams (mg) 3 times a day. However, the dose is usually not more than 80 mg 3 times a day. There was no increase in adverse events with the higher dose. Conclusions: Sildenafil at 50 mg or 100 mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC.

Condition	Reason	Notes
Nitrate therapy in patients	Severe hypotension	Absolute contraindication
Severe hepatic impairment	Altered metabolism	Use with caution
Retinitis pigmentosa	Possible retinal toxicity	Consult ophthalmologist
Hypotension (<90/50 mmHg)	Risk of exacerbating low BP	Monitor blood pressure

Sildenafil 100 mg improved the sexual experience and treatment satisfaction, and reduced feelings of anxiety compared with the 50-mg dose. Pronunciation: sil-DEN-a-fil Generic name: sildenafil Brand names: Revatio, Viagra, Vybrique Dosage form: tablets (20 mg; 25 mg, 50 mg, 100 mg), injection (10 mg/12.5 mL), oral suspension (10 mg/mL), oral film (25 mg, 50 mg, 75 mg, 100 mg) Drug classes: Agents for pulmonary hypertension, Impotence medications Sildenafil is used to treat erectile dysfunction (ED) in adult men or pulmonary arterial hypertension (PAH) in adults and children, depending on the brand or formulation.

• Sildenafil molecules work by relaxing smooth muscle tissue.
• This relaxation allows increased blood flow in blood vessels.
• It is less effective without sexual arousal.
• Some common brand names include Viagra, Revatio, and Kamagra.
• Sildenafil's patent expired, leading to numerous generics.
• Generic versions are usually more affordable.
• It’s important to follow prescription instructions strictly.
• Using more than the recommended dose can be dangerous.