Ärztin für Psychiatrie und Psychotherapie
Dipl. prozessorientierte Psychotherapeutin ASP
Winterthur · Berlin
Dapoxetine for premature ejaculation
If necessary, the dose may be increased in a stepwise fashion until a therapeutic effect is achieved or the maximum daily recommended dose is reached.
- Dapoxetine is marketed under various brand names likePriligy.
- It’s designed specifically for men experiencing premature ejaculation.
- The medication works by increasing serotonin levels in nerve cells.
- Use dapoxetine consistently as prescribed for maximum benefit.
- It is not intended for daily use but as needed before sex.
- Always inform your doctor about other medications to avoid interactions.
No exact schedule for increasing the dose has been established; the experience of the physician, the response of the patient, the adverse effects experienced by the patient, and other general medical considerations should be the guiding factors.
Medicine brands for Dapoxetine
Premature ejaculation that relates to erectile dysfunction may resolve if the erectile dysfunction is treated successfully. If a patient has depression-related erectile dysfunction but not premature ejaculation, a drug with minimal adverse sexual effects might be considered so as to avoid causing delayed ejaculation or even anorgasmia. [24] However, if the patient has premature ejaculation, erectile dysfunction, and depression, an antidepressant with SSRI side effects has the added benefit of possibly alleviating the premature ejaculation. In Korea and other areas of the Far East, SS (Super Secret) cream (a combination of 9 ingredients, mainly herbal) has been shown to desensitize the penis, decrease the vibratory threshold, and help men with premature ejaculation to delay their ejaculatory response significantly. [26, 27] This preparation is not yet approved by the FDA.
Common side effects of Dapoxetine
Simple combinations of lidocaine cream or related topical anesthetic agents can also be effective. These combinations are safe as long as the patient has no history of allergy to the substance. [28, 29, 30, 31] A metered-dose lidocaine-prilocaine cutaneous spray (Fortacin) is approved in Europe. The most effective pharmacologic therapy for premature ejaculation is to administer a drug from the SSRI class. Normally, these drugs are used as antidepressants dapoxetine 60 mg buy online in the clinical setting.
Estimated impact for the NHS
Many of these agents were found to have the side effect of significantly delaying the achievement of orgasm in both male and female patients, and it was for this reason that such agents were applied to the treatment of premature ejaculation. Some tricyclic antidepressants (TCAs) with SSRI-like activity have the same effect in orgasm that SSRIs do. The TCA that has been most frequently studied for treatment of premature ejaculation is clomipramine. [33, 34, 35, 36] Many investigators find that clomipramine is more effective for premature ejaculation than many SSRIs are. Results of a multicenter, randomized, double-blind, placebo-controlled, fixed-dose clinical phase III study in 159 Korean patients suggest that 15 mg of clomipramine taken approximately 2-6 hours before sexual intercourse is effective and safe for treatment of premature ejaculation. If the initial SSRI fails to help the patient, it is certainly reasonable to try a second agent.
| Study/Source | Efficacy Rate | Satisfaction Level | Notes |
|---|---|---|---|
| Clinical Trial (2022) | 70-80% | High | Significant improvement in ejaculation latency |
| Patient Surveys (2023) | 75% | Very satisfied | Many report improved sexual confidence |
| Meta-Analysis (2021) | 65-85% | Varies | Effectiveness depends on dosage and severity of PE |
| Long-Term Use Reports (2024) | Maintains benefit | Consistent | Most users report sustained effect over time |
However, if the second choice fails, it is not likely that a third choice will offer any benefit.
| Country | Approval Status | Notes |
|---|---|---|
| USA | Approved by FDA for PE | Prescription required |
| European Union | Approved in several countries | Prescription essential |
| Australia | Approved for PE | Sold under brand names |
| India | Available OTC in some pharmacies | Consult healthcare provider before use |
| Canada | Approved with prescription | Used for PE treatment |
As with treatment for depression, if a patient has been taking the maximal dose of the medication for 6 weeks without showing any improvement, the likelihood that a more prolonged course of therapy with a particular drug would be successful is remote.
- Dapoxetine can improve confidence and sexual satisfaction.
- It is contraindicated in men with severe heart or liver conditions.
- The optimal dose varies; typically, 30 mg or 60 mg based on tolerance.
- Do not take dapoxetine with other SSRIs or serotonin drugs without medical advice.
- The onset of action is usually within 1-3 hours after intake.
- Dapoxetine is rapidly absorbed and eliminated from the body.
There is no reason why pharmacotherapy cannot be combined with behavioral modification therapy, desensitizing creams, or both; the use of several simultaneous treatments can result in additive effects or even synergy.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Kamagra 100 mg | 100 mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Cialis Generic | 2.5mg | 30 + 4 Pills | 51.95€ 49.48€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Cialis Super Active | 20mg | 10 Pills | 55.64€ 52.99€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Levitra Generic | 10mg | 270 + 10 Pills | 338.09€ 321.99€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Viagra Generic | 50mg | 360 + 10 Pills | 225.33€ 214.60€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Levitra Generic | 10mg | 10 Pills | 28.93€ 27.55€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ |
If all treatment fails, then the patient’s only options are as follows: To see a different health care professional, if he wishes To accept his condition as
Can I get dapoxetine (Priligy) on the NHS?
[37] However, a systematic review and meta-analysis concluded that below a dose of 50 mg, a higher dose of clomipramine results in a longer delay of ejaculation without an increased risk of adverse events. In most cases, females require considerably more time to reach climax than males do; thus, in females taking SSRIs and SSRI-like agents, the delayed climax caused by these agents becomes an adverse effect. In many females, such an inability to reach orgasm can induce a pattern of sexual avoidance, along with a corresponding decrease in libido or sexual excitement (lubrication). In males, too-rapid orgasm can cause some of the same patterns of sexual avoidance and decreased libido. Thus, it is essential to determine the primary problem when instituting therapy.
How does Priligy work?
SSRIs useful for treating premature ejaculation include the following: A systematic review and meta-analysis reported that although fluoxetine was more effective than placebo in treating PE, sertraline and paroxetine were more effective than fluoxetine (p < 0.05). Dapoxetine, which is generally categorized as a fast-acting SSRI, was developed specifically to treat this condition. It may be effective at the first dose (ie, on demand) when given 1-3 hours before sexual intercourse, and its adverse-effect profile is comparable to those of other SSRIs. [41, 42, 43] Dapoxetine has been approved in a number of countries but not yet in the United States. In a study of men with both premature ejaculation and erectile dysfunction who were on phosphodiesterase type 5 (PDE5) therapy, dapoxetine provided treatment benefit and was generally well tolerated.
Patient-reported global impression of change (PGIC)
[44] However, up to 90% of patients discontinue dapoxetine, mostly because of adverse effects, cost, and disappointing efficacy. The optimal medical treatment regimen for premature ejaculation has not been established. The author’s experience has been that in some males, single dosing before sexual relations can work well, whereas in others, it may be necessary to achieve and maintain a target blood level through daily use of the medication, as in the treatment of clinical depression. Obviously, if single dosing is successful, therapy is simpler and has fewer adverse effects. Accordingly, this may be the preferred initial approach. being untreatable with currently available therapeutic options Adverse effects of long-term SSRI use are a significant concern and should be considered by both the physician and the patient.
Additional information
Dapoxetine is available on prescription in some NHS health authority areas, usually after specialist referral and advice - please check with your local GP surgery. NHS doctors will also usually be able to write private prescriptions for dapoxetine (charges will apply). Authored 28 July 2020 by Dr A. Reviewed by Dr C. Pugh, Dr B.
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Babor Last reviewed 19 June 2023 Last updated 3 December 2025 Editorial policy Medical treatment for premature (early) ejaculation includes several options. Any serious primary medical condition (eg, angina) should be treated; for the purposes of the following discussion, the patient is assumed to be healthy, and premature ejaculation is assumed to be his only problem. In addition, any accompanying erection problem (eg, erectile dysfunction [ED]) should be treated; various methods are available, and excellent success can be expected. Accordingly, treatment of concomitant ED is mentioned only in passing. To achieve the best outcome, the female partner should be included as fully as possible in the treatment and counseling sessions.
Dapoxetine Uses
Pharmacologic therapy may include selective serotonin reuptake inhibitors (SSRIs) or topical desensitizing agents. Outpatient care can be scheduled as appropriate for the clinical circumstances. To date, no drug has been specifically approved by the US Food and Drug Administration (FDA) for the treatment of premature ejaculation. However, numerous studies have shown that selective serotonin reuptake inhibitors (SSRIs) and drugs with SSRI-like side effects are safe and effective to treat this condition, and many physicians use these agents for this purpose. Topical desensitizing therapy with local anesthetic agents can also be useful in some men with premature ejaculation. [45] Such adverse effects may include the following: Sexual side effects other than delayed ejaculation (eg, erectile dysfunction or loss of libido) In addition, caution should be exercised in changing SSRIs; a washout period is necessary to avoid overdose.
| Parameter | Guideline |
|---|---|
| Recommended Dose | 30 mg to start; possible increase to 60 mg if needed |
| Timing Before Sex | 1 to 3 hours prior |
| Frequency of Use | No more than once per day |
| Consumption with Food | Usually taken with or without food, consistency advised |
| Alcohol Interaction | Avoid alcohol; increases side effects |
| Precautions | Not suitable for certain health conditions, consult doctor |
SSRI discontinuance syndrome (especially with paroxetine) has been associated with dose reduction or discontinuance and may cause dizziness, nausea and vomiting, headache, gait instability, lethargy, agitation, anxiety, and insomnia.
Is Priligy suitable for me?
You should not take a dose more than once every 24 hours and do not take it every day. It is possible that grapefruit juice will cause the dapoxetine (Priligy) to stay in your system longer, so you should wait 24 hours after drinking grapefruit juice before taking dapoxetine. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism, which can lead to a rise in levels of many drugs in your blood. Men usually get on well with dapoxetine (Priligy). The most common side effects are dizziness due to lower blood pressure, nausea, and headache.
Priligy warnings
The full list of side effects is in the patient information leaflet. You are more likely to have side effects if taking alcohol, recreational drugs (such as LSD, heroin, methadone), or sleeping tablets at the same time as Priligy. There are some interactions with other drugs and some herbal remedies. The online consultation questionnaire checks if your medication is unsuitable to take with Priligy. Priligy is only licensed for use by men aged between 18 and 64 years.
Cardiovascular considerations
The effectiveness and safety of Priligy has not been established in patients aged 65 years and over. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take dapoxetine (Priligy). Most men benefit from dapoxetine (Priligy), but psychological therapies and direct physical treatments can be used at the same time and may increase the benefit. Priligy was first launched in the UK in 2013 and remained under patent until October 2025, so only the drug company Menarini could produce and sell the medicine. When the patent expired, lower cost generic/unbranded versions became available and Menarini decided to no longer market Priligy. Some studies have demonstrated that combining phosphodiesterase type 5 (PDE5) inhibitors with SSRIs provides better results in the treatment of premature ejaculation than using SSRIs alone.