User Reviews and Experiences with ED Topical Solutions

Learning more about ED and your treatment options is a solid first step in figuring it out. Check out our blog posts on the latest ED treatments, remedies for premature ejaculation (PE), and how to get hard.

How ED Creams Work: The Science Behind the Solutions

Fortunately, though, there are many other ED treatments with plenty of satisfied customers. Here’s what to keep in mind when considering ED creams: The only FDA-authorized ED gel is Eroxon. Over-the-counter Eroxon is available without a prescription and works by cooling and heating the penis, stimulating the nerves to improve blood flow. The only FDA-authorized ED gel is Eroxon. Many “natural” products are marketed for improving erectile function and enhancing sexual performance — but there’s very little proof they work.

Cost and Insurance Coverage

Since the FDA doesn’t test or approve these supplements in the same way it regulates medications, they may contain harmful ingredients. There are legit alternatives to erectile dysfunction creams and gels. While very few ED creams and gels are on the market, numerous safe and highly effective erectile dysfunction treatments are available. Therapy can also be helpful if your ED has psychological roots, like anxiety. Erectile dysfunction can be frustrating to deal with, but it is treatable. Our online platform can connect you with a healthcare professional today. Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review.

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	5mg	90 + 6 Pills	115.91€ 110.39€	Buy
Levitra Professional	20mg	60 + 2 Pills	223.11€ 212.49€	Buy
Cialis Black	80mg	20 Pills	71.83€ 68.41€	Buy
Levitra Soft Tabs	20mg	10 Pills	52.27€ 49.78€	Buy
Apcalis SX Oral Jelly	20mg	17 + 4 Sachets	95.52€ 90.97€	Buy
Cialis Generic	60mg	360 + 10 Pills	570.52€ 543.35€	Buy
Viagra Generic	150mg	30 + 2 Pills	72.32€ 68.88€	Buy
Kamagra Polo	100 mg	20 Pills	83.56€ 79.58€	Buy
Cialis Black	80mg	120 + 8 Pills	264.77€ 252.16€	Buy
Cialis Generic	20mg	270 + 10 Pills	335.21€ 319.25€	Buy
Tadalista Super Active	20mg	30 + 6 Pills	128.09€ 121.99€	Buy
Viagra Professional	100mg	30 Pills	88.92€ 84.69€	Buy
Levitra Generic	40mg	270 + 10 Pills	561.89€ 535.13€	Buy
Levitra Generic	60mg	20 Pills	81.30€ 77.43€	Buy
Levitra Original	20mg	12 Pills	81.99€ 78.09€	Buy
Viagra Generic	150mg	60 + 4 Pills	111.25€ 105.95€	Buy

SST completes Phase I trial of SST-6006 to treat erectile dysfunction in men. Alprostadil cream in tadalis sx 20 mg the treatment of erectile dysfunction: clinical evidence and experience. A review on phosphodiesterase-5 inhibitors as a topical therapy for erectile dysfunction. Counterfeit phosphodiesterase type 5 inhibitors pose significant safety risks. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. U.S. Food and Drug Administration (FDA). Scoping review exploring advancements in topical agent therapies for erectile dysfunction.

Choosing the Right ED Cream for You

It should be used five to 30 minutes before attempting intercourse. Research found that alprostadil was significantly more effective than a placebo in patients with ED. Since alprostadil mostly remains in the genital area and doesn’t spread to the rest of the body, the cream doesn’t seem to interact with other medications. With that in mind, it might be a good alternative to PDE5 inhibitors, as it can be safer for folks who use nitrates, alpha-blockers, and blood pressure medication. A 2017 study of men with type 2 diabetes and ED suggests that alprostadil cream may be an effective alternative for those who can’t (or prefer not to) take ED pills or who haven’t seen good results from standard ED medications.

Full Text Sources

There’s just one problem: Alprostadil cream isn’t FDA-approved, and for that reason, you can’t buy it in the U.S. At least, not yet. However, the FDA has approved Caverject®, an alprostadil-based injection for the treatment of erectile dysfunction. SST-6006 is a topical cream containing sildenafil. Though some studies have looked into the possibility of using sildenafil gel or cream, it’s not commercially available yet.

FDA Warnings

A company called Strategic Science & Technologies LLC announced it had completed a phase 2A clinical trial of an SST-6006 product in 2017 and currently says it’s “actively engaged in partner discussions.” So for now, sildenafil gel isn’t yet a thing — but that might change in the future. If you’ve looked for supplements for erectile dysfunction, you’ve probably come across l-arginine. Many believe l-arginine can improve erectile function and sexual performance. This supplement is available in stores and online. L-arginine is linked to nitric oxide production. A double-blind placebo-controlled evaluation of the effect of topical sildenafil on erectile dysfunction. Alpostadil in cream — a new option of treating erectile dysfunctions in diabetes. Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

Method	Typical Dosage/Use Frequency	Application Area	Additional Tips
Topical Creams	Apply 2-3 times daily	Penis shaft and glans	Wash hands after application
Gel Application	Use a pea-sized amount	Penile surface	Avoid contact with eyes
Ointments	Once before sexual activity	Penile skin	Conduct patch test beforehand
Spray	As needed	External genital area	Avoid inhalation, wash hands afterward

Dr.

• The safety profile of topical ED creams is generally favorable when used as directed.
• They don't typically interfere with other medications when properly used.
• Some formulations may last longer, providing up to an hour of effectiveness.
• Use of lubricants can improve application and comfort.
• Always discard expired creams and follow disposal guidelines.

Kelly Brown is a board certified Urologist and fellowship trained in Andrology. She is an accomplished men’s health expert with a robust background in healthcare innovation, clinical medicine, and academic research.

Medication Type	Possible Interaction	Risk Level	Recommendations
Nitrate medications (for heart)	Increased risk of severe hypotension	High	Do not use without doctor consultation
Blood pressure medications	Potential blood pressure changes	Moderate	Consult healthcare provider
Other hormonal therapies	Altered hormone balance	Moderate	Medical supervision required
Antidepressants	Possible worsening of side effects or reduced efficacy	Low to moderate	Talk to doctor before use

Dr.

User Demographic	Preferred Cream Type	Satisfaction Level	Reasons for Preference	Comments
Age 30-40	Natural ingredients	4.5/5	Fewer side effects	"Works well with minimal irritation"
Age 50-60	Fast-acting gels	4.2/5	Quick onset, discreet application	"Easy to use before intimacy"
Age 20-30	Herbal-based creams	4.3/5	Natural approach, safety concern	"Trusted natural ingredients"
General audience	Multi-ingredient formulas	4.0/5	Broader efficacy	"Love that it enhances confidence"

Brown was previously Medical Director of a male fertility startup where she lead strategy and design of their digital health platform, an innovative education and telehealth model for delivering expert male fertility care.

Other Topical Agents: Papaverine, Verapamil, and More

Indeed, nitric oxide plays a critical role in erectile function because it helps blood vessels relax, thus improving blood flow to the penis. Having said that, research on l-Arginine creams and other forms of nitric oxide cream for erectile dysfunction is basically non-existent. Other supposed ED creams contain natural ingredients like ginkgo biloba leaf, tree bark extract, and cuscuta seed. Many assume these products are safe because they’re “natural.” But we’d like to point out that poison ivy is also natural — and you’d probably never put it on your penis. Since these herbal remedies are supplements, they aren’t regulated or tested by the FDA in the same way medications are.

Key Takeaways

Besides the fact that they may not actually work, the FDA warns that many so-called “sexual enhancement” treatments contain dodgy ingredients and potentially harmful contaminants. When it comes to your health, you’re wise to stick to safe, regulated treatments that are proven to be effective. As with most medical treatments, erection creams and gels may have side effects and safety considerations. For instance, you could experience an allergic reaction to the ingredients. Another common side effect is skin irritation.

Ingredients and Potential Allergies

As you know, the skin on and around the genitals is particularly sensitive, so some topical treatments might cause tingling or burning. This can affect your partner, too, who could experience anal or vaginal burning. Be sure to check if your partner has any allergies before using an ED cream or gel with them. There’s also a possibility of priapism — a prolonged erection lasting more than four hours. Priapism is often painful and requires urgent medical treatment. She completed her undergraduate studies at University of North Carolina at Chapel Hill (go Heels!) with a Bachelor of Science in Radiologic Science and a Minor in Chemistry.

• Total Man Cream: A topical solution claiming to address all aspects of erectile health.
• Vigor Rush Cream: Marketed for a quick and powerful improvement in erections.
• Ultra Hard Cream: Advertised to deliver superior hardness and durability.
• Max Endurance Cream: A product for prolonged sexual activity and satisfaction.
• Hard Impact Cream: Claims to make a significant difference in erection performance.
• Performance Boost Cream: Designed to enhance every facet of sexual experience.

She took a position at University of California Los Angeles as a radiologic technologist in the department of Interventional Cardiology, further solidifying her passion for medicine. She also pursued the unique opportunity to lead departmental design and operational development at the Ronald Reagan UCLA Medical Center, sparking her passion for the business of healthcare. Dr. Brown then went on to obtain her doctorate in medicine from the prestigious Northwestern University - Feinberg School of Medicine and Masters in Business Administration from Northwestern University - Kellogg School of Management, with a concentration in Healthcare Management. During her surgical residency in Urology at University of California San Francisco, she utilized her research year to focus on innovations in telemedicine and then served as chief resident with significant contributions to clinical quality improvement. Dr. Brown then completed her Andrology Fellowship at Medical College of Wisconsin, furthering her expertise in male fertility, microsurgery, and sexual function. Her dedication to caring for patients with compassion, understanding, as well as a unique ability to make guys instantly comfortable discussing anything from sex to sperm makes her a renowned clinician. In addition, her passion for innovation in healthcare combined with her business acumen makes her a formidable leader in the field of men’s health.

Who Should Avoid Topical ED Creams?

Beyond potential side effects, these products just may not work for you. If erectile cream or gel isn’t giving you results, even after a few attempts, consider speaking with a healthcare provider about other options. You shouldn’t use alprostadil cream if you have certain medical conditions, including: Peyronie’s disease (penile scar tissue buildup) and other deformities of the penis Peyronie’s disease (penile scar tissue buildup) and other deformities of the penis You should also avoid Eroxon if you have: An allergy to any of the ingredients An allergy to any of the ingredients Peyronie’s disease or other deformities of the penis Peyronie’s disease or other deformities of the penis Sore, damaged, or irritated skin on the penis Sore, damaged, or irritated skin on the penis If you have a condition that makes it risky to use erectile dysfunction creams, consult a medical professional about alternative treatments. You might even benefit from a few natural ways to protect erectile function. Certain lifestyle changes can vardenafil oral improve your erections and overall sexual health.

Alprostadil Cream

A 2024 study of topical ED products suggests that they can be helpful for many men. But the research stopped short of declaring them as effective as or better than ED medications, such as PDE5 inhibitors. At this point, very few ED creams and gels are backed by research, and only one has been authorized by the FDA. That said, there are quite a few alternatives to ED creams and gels in the form of oral medications. While erectile dysfunction can be caused by physical ailments like cardiovascular disease, psychological factors may also come into play.

Is there any ointment for erectile dysfunction?

Your ED could be due to mental health issues like anxiety, depression, or sexual performance anxiety. If you’re experiencing psychological ED, consider in-person or online therapy. Seeking treatment for mental health can lead to better erectile function while helping you feel better overall. What is the best cream for erectile dysfunction? Erectile dysfunction creams and gels may seem great in theory, but few are available for purchase.